Blood Clots Could Be the Root Reason for All Coronary heart Illness

On this interview, repeat visitor Dr. Malcolm Kendrick, a board-certified household doctor and writer of the e-book, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” opinions the underlying mechanisms for coronary heart illness, which for the final century has been the main explanation for demise within the U.S.

Of all of the books he’s written, that is my favourite, because it goes into nice element, providing you with the organic understanding of the method of atherosclerosis resulting in coronary heart assaults and strokes. He additionally has stable methods for decreasing your heart problems danger.

By the way, when you perceive the illness course of, then it’s also possible to perceive how each COVID-19 and the COVID jab can contribute to coronary heart illness. When requested why he’s taken such an curiosity in coronary heart illness, Kendrick replies:

“Once I was coaching as a scholar in medication, Scotland had the best fee of coronary heart illness on the planet. Early on the reply for why was, ‘Oh, properly, it is as a result of we now have such horrible food plan, and we eat garbage meals like deep fried Mars bars.’

So, you eat an excessive amount of saturated fats, the saturated fats will get become ldl cholesterol in your bloodstream, after which it’s absorbed into arteries and kinds narrowings and thickenings, which all sounds believable when you do not give it some thought too arduous.

However I additionally occur to go to France quite a bit, and what I seen about France was, they eat numerous saturated fats. They eat extra, in actual fact, than anybody else in Europe, and definitely greater than Scotland. So, [this saturated fat] speculation definitely did not work for the French. They’ve the best saturated fats consumption in Europe and lowest fee of coronary heart illness, and this has been the case for many years.

When you took all the chance components for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had barely [higher risk], in line with standard considering. However, in actual fact, they’d one-fifth [the rate among age-matched men].

So, I assumed, that is attention-grabbing. It does not make a lot sense in line with what we’re informed. Then whereas I used to be in medical college, a tutor in cardiology stated … LDL can not cross the endothelium. On the time, I did not know what LDL was, nor did I do know what the endothelium was, however it sounded vital.

She had been coronary heart illness as a special course of for many years … So, I believe that is actually the place I obtained began. When you begin questioning what the issue is, you find yourself questioning an increasing number of and also you begin considering, gosh, that is simply nonsense, is not it? This entire speculation is simply nonsense. So, I began choosing it aside.”

The Thrombogenic Speculation

“The Clot Thickens” is Kendrick’s effort to elucidate another speculation for what really causes coronary heart illness. If it’s not saturated fats and ldl cholesterol, what’s it? In 1852, a Viennese researcher, Karl von Rokitansky, developed what he known as the encrustation speculation of coronary heart illness.

As we speak, this speculation has been renamed the thrombogenic speculation. ‘Thrombo’ stands for thrombosis, i.e., blood clots, and ‘genesis’ means the reason for, or the beginning of. So, the thrombogenic speculation is that blood clots are the fundamental pathology that causes all coronary heart illness.

In a nutshell, when a blood clot kinds in your artery wall, which may occur for plenty of causes, it should usually be coated over and dissolved. An issue arises, nonetheless, if the blood clot will not be totally eradicated and one other blood clot kinds in the identical ‘susceptible’ space. This then turns into what’s conventionally known as atherosclerotic plaque.

“The atherosclerotic plaque is principally a buildup of blood clot, restore, blood clot, restore, blood clot, restore,” Kendrick explains. “If the blood clotting course of is quicker than the restore course of, you’ve got a plaque that progressively grows and ultimately thickens the artery wall till it narrows sufficiently that the ultimate blood clot, on prime of the present plaque, is the factor that may trigger a coronary heart assault or stroke …

When you lower via the plaque and take a look at it, it virtually seems like tree rings. You’ll be able to see there’s been a clot, restore, clot, restore, clot, restore, clock, restore over time.

It’s broadly accepted {that a} blood clot forming on an current plaque will trigger the plaque to develop in measurement. Yow will discover 10,000 papers saying that that is the case. What the mainstream will not settle for is {that a} blood clot on a wholesome artery wall can provoke the entire course of.

So, to an extent, all I am saying to folks is, properly, we all know blood clots trigger the ultimate occasion. We all know blood clots trigger plaques to develop. Why will not you settle for that blood clots are the factor that begins it within the first place? As a result of then we now have one course of throughout, and it is smart, as a result of it matches with what you’ll be able to see.”

As famous by Kendrick, the traditional view is that low-density lipoprotein or LDL will get into the artery wall the place it initiates plaque formation. It then, inexplicably, stops initiating plaque, and the plaque continues to develop via the addition of repeated clots.

Nonetheless, Kendrick says, when you begin drilling down into the ldl cholesterol, aka LDL speculation, the entire thing begins to disintegrate. LDL merely can not clarify the illness development. But regardless of the numerous holes within the principle, the concept LDL causes coronary heart illness is touted as an absolute, proven fact.

What’s the Mechanism?

With the intention to justify a speculation, it’s good to have a mechanism of motion. When you perceive the mechanism of the particular illness course of, then you’ll be able to put the puzzle items collectively. Kendrick begins his clarification:

“Your blood vessels are lined with endothelial cells, a bit like tiles on a wall. Endothelial cells are additionally coated themselves in a factor known as glycocalyx. When you attempt to decide up a fish, it will slip via your fingers; it is very slippery. The rationale it is slippery is as a result of it’s coated in glycocalyx and the glycocalyx is extremely slippery. It is nature’s Teflon.

So principally, in our case, the glycocalyx [is inside] our blood vessels, to permit the blood to journey via with out it sticking, with out harm occurring. So, you’ve got this sort of damage-repellent layer on prime of your endothelial cells.

Now, if that layer is broken, after which the endothelial cell itself beneath is broken, then the physique will say, ‘Oh, we have harm to a blood vessel, we should have a blood clot there as a result of we might bleed out.’ So, a blood clot kinds on the world of harm, and instantly stops [the bleeding].”

The blood clot doesn’t simply carry on rising and rising. If it did, you’d die anytime you had a blood clot. As a substitute, when a clot kinds, different processes step in to stop it getting too huge, which is why each blood clot doesn’t trigger a stroke or coronary heart assault. As soon as the clot has stabilized, and has been shaved down, the world is roofed over by endothelial progenitor cells, made within the bone marrow, that float round in your blood stream.

When a progenitor cell finds an space that has been broken, it attaches itself to that space, together with others, forming a brand new endothelial layer. The remaining blood clot is now mendacity ‘inside’ the artery wall itself. So, principally, it’s the restore course of that may result in plaque buildup inside the artery wall. In time, if harm outstrips restore, this could slim the artery and cut back blood move.

What Damages Endothelial Cells?

The query is, what can harm the endothelium within the first place? Right here, Kendrick makes use of the SARS-CoV-2 mechanism for instance:

“The COVID virus enters endothelial cells via the ACE2 receptor. It prefers endothelial cells as a result of they have ACE2 receptors on them. It will get into the endothelial cell and begins replicating, then bursts out, damaging the cell. Bingo, you’ve obtained an space of harm.

In fact, added to this, when cells have viruses inside them, they ship out misery indicators to the immune system saying, ‘I have been contaminated, come and kill me,’ and so the immune system begins to have a go on the endothelial cells. This is the reason you will get an issue, as a result of the endothelial cells are being broken and stripped off.

Blood clotting happens on the factors of harm and hey, presto, you are having clotting, you are having strokes, you are having coronary heart assaults, which is the factor that individuals at first could not perceive [about COVID-19]. But it is very clear that what’s occurring is you’ve got obtained harm to the endothelial cells.

Clearly, you and I each know that when you get a [COVID jab], the cells are triggered to provide the spike protein, and these cells are sending out misery messages saying, ‘I’m contaminated.’ It’s a must to be very cautious if you wish to stick one thing into cells that then says to the immune system, ‘Please come and destroy me,’ as a result of that is what the immune system goes to do.

However transferring on from that, what different factor may cause endothelial harm? The reply is issues like smoking. Smoke particles get out of your lungs, they go into your blood vessels and so they trigger harm … You smoke one cigarette and an entire bunch of microparticles seem in your bloodstream, which suggests endothelial cells are dying.

Fortunately as endothelial cells die, one other message is shipped to the bone marrow saying, we want extra endothelial cells and it stimulates endothelial progenitor cell manufacturing. These endothelial progenitor cells rush round masking over the areas of harm.

Some people who smoke have sufficient restore occurring and once you’re youthful, it is okay. As you become old and your restore techniques start to fail a bit, cigarette smoking turns into an increasing number of of an issue.”

Different issues that may trigger endothelial harm embody:

Repairing the Glycocalyx

As defined by Kendrick, the glycocalyx layer resembles a garden, with slippery filaments that stick up. Inside this glycocalyx layer you’ve got nitric oxide synthase (NOS), which produces nitric oxide (NO), and you’ve got NO itself, in addition to plenty of different anticoagulant proteins. The glycocalyx is definitely a potent anticoagulant layer, so it stops blood clots forming. If glycocalyx is broken, your danger of blood clotting will increase.

“It’s a really sophisticated layer,” Kendrick says. “It is like a jungle filled with issues that say, ‘Do not keep on with this, keep away from this.’” Inside it, you even have albumin, protein advanced produced by the liver. Albumin comprises the proteins that assist keep and restore the glycocalyx. A truth that almost all medical doctors are unaware of is that, if in case you have a low albumin stage, you are considerably extra more likely to die of coronary heart illness.

The excellent news is that whereas the glycocalyx layer might be quickly destroyed, it may also be quickly repaired. (Experiments have proven that in an space the place the glycocalyx has been fully stripped off, it may be fully repaired in a single second.) Dietary supplements like chondroitin sulfate and methylsulfonylmethane (MSM) might be useful on this regard.

“When you try to clarify that via the LDL mechanism, it simply does not work,” Kendrick says. “They’ve found that when you give chondroitin sulfate as a complement — which usually is for arthritis and stuff like that — it reduces the chance of coronary heart illness fairly significantly. How do you clarify that? Nicely, you’ll be able to clarify that since you’re defending your glycocalyx.

These are the form of issues that make no sense when you like wanting on the standard concepts of coronary heart illness, however are instantly and simply defined when you say, ‘We’ve to maintain our glycocalyx wholesome and we now have to maintain our endothelial cells beneath them wholesome.

In any other case they are going to be broken and stripped off, after which we’ll get a blood clot, and if we maintain getting blood clots at that time, we’ll find yourself with a plaque and ultimately one of many blood clots on that plaque will kill you from a coronary heart assault or a stroke.”

Blood Circulation Restriction Coaching

A life-style technique that may assist restore endothelial harm is blood move restriction (BFR) coaching. In response to BFR, your physique produces vascular endothelial development issue (VEGF), which acts as “fertilizer” for the endothelium. You’ll be able to be taught the ins and outs of BFR in my free BFR report. VEGF additionally induces the synthesis of nitric oxide (NO), a potent vasodilator, and it stimulates endothelial progenitor cells.

“NO protects the endothelium. It’s anticoagulant — probably the most potent anticoagulant we now have within the physique. It’s actually the magic molecule for cardiovascular well being,” Kendrick says.

“At one time NO was often known as Endothelial Derived Leisure Issue (EDRF) NO was one thing nobody believed might probably exist within the human physique. NO is definitely a free radical. Everybody says free radicals are terribly damaging and unhealthy.

To that I reply, ‘Nicely, you could want to know that the chemical that’s the single most vital protecting chemical within the physique for the cardiovascular system is an extremely free radical known as nitric oxide.”

Some anticancer medicine are designed to dam VEGF, because the tumor wants angiogenesis — which is the creation of recent blood vessels which might be required to supply adequate ‘vitamins’ With out these new blood vessels, the tumor dies off. Sadly, when you block VEGF, you additionally block NO, which then raises your danger for coronary heart illness.

“These medicine have been virtually faraway from the market,” Kendrick says, “as a result of regardless of their anticancer exercise, they have been procardiovascular illness to fairly a scary diploma.

[That’s why], if you’re given bevacizumab or Avastin as an anticancer drug, they now provide you with angiotensin changing enzyme inhibitors (ACE inhibitors), that are blood stress decreasing tablets, and ACE inhibitors have a particular influence on bradykinin, which will increase NO synthesis.”

Methods to Decrease Your Thrombotic Threat

In his e-book, “The Clot Thickens: The Enduring Thriller of Coronary heart Illness,” Kendrick opinions many alternative methods that may decrease your illness danger. Right here’s a short-list of examples coated in far better depth within the e-book, in addition to a few of my very own suggestions that I carry up within the interview: