Korean fermented meals Doenjang exhibits promise in assuaging menopausal signs

In a latest research revealed within the journal Vitamins, researchers examine the efficacy between conventional and industrial Doenjang in assuaging menopausal syndrome.

Research: Analysis of menopausal syndrome aid and anti-obesity efficacy of the Korean fermented meals doenjang: a randomized, double-blind scientific trial. Picture Credit score: mino choi / Shutterstock.com

Treating menopause

Menopause results in hormonal modifications which will trigger psychological and bodily signs like sizzling flashes, sleep disturbances, insomnia, sweating, atrophy of the genitourinary system, and nervousness. Menopausal signs are sometimes handled with hormone substitute remedy (HRT), primarily progesterone and estrogen.

Soy consumption, particularly in Asian international locations, is related to decrease charges of menopausal signs, thereby providing a pure substitute for HRT when it could be contraindicated or in any other case undesirable as a consequence of attainable unintended effects akin to breast most cancers or heart problems.

Doenjang, a type of soybean paste consumed in Korea, is wealthy in antioxidants and fermented with helpful microorganisms like Bacillus subtilis, Aspergillus oryzae, Rhizopus, and Mucor. Beforehand, Doenjang has been recognized as a possible resolution for assuaging menopausal signs; nevertheless, cautious analysis is required to establish formulations which may be handiest for this objective.

Concerning the research

Within the present research, researchers performed an eight-week randomized and double-blind scientific trial involving postmenopausal girls with menopausal syndrome.

The Kupperman index is a extensively accepted diagnostic instrument for menopausal syndrome that measures a variety of vasomotor, urinary tract, psychoneurological, motor, digestive, and systemic signs. Scores beneath 20 point out gentle signs, whereas these between 20 and 40 signify reasonable severity. Scores exceeding 40 point out extreme signs and scores of 60 or extra denote a very extreme manifestation of the syndrome.

Contributors acquired Doenjang supplementation in three varieties, together with high-content helpful microorganism conventional Doenjang (HDC), low-content helpful microorganism conventional Doenjang (LDC), and commercially obtainable Doenjang (CD).

Remedy compliance, important indicators, and unintended effects have been evaluated after 4 weeks of supplementation. Researchers collected measures of menopausal syndrome aid, together with the Kupperman index, originally and finish of the trial, together with bioelectrical impedance evaluation (BIA) outcomes, weight, lipid profiles, serum blood markers, and inflammatory markers.

Security assessments included blood chemistry, hematological assessments, and monitoring for unintended effects. Weight problems indicators and irritation markers have been additionally assessed, as have been modifications within the intestine microbiome analyzed by way of stool assessments.

Doenjang drugs have been ready by way of a standard fermentation course of and freeze-dried for scientific trials. Statistical evaluation included chi-square assessments, evaluation of variance (ANOVA), and paired t-tests to check baseline and post-intervention knowledge.

Research findings

A complete of 56 people have been included within the research and acquired HDC, LDC, or CD, none of whom reported any opposed occasions. Anthropometric parameters, together with age, weight, and physique mass index (BMI), didn’t differ considerably among the many research members.

Security assessments indicated no opposed results on liver or kidney perform, with some enhancements in blood urea nitrogen (BUN), uric acid, and complete protein ranges within the HDC group. Doenjang was not related to anti-obesity results; nevertheless, its use lowered LDL levels of cholesterol.

Kupperman index scores considerably decreased in all teams following the administration of Doenjang, with enhancements noticed in varied signs. Microbiome evaluation confirmed decreased Firmicutes and elevated Bacteroidetes throughout all teams, with helpful micro organism growing and dangerous micro organism reducing, significantly within the CD group.

Quick-chain fatty acid evaluation indicated assorted results throughout teams. General, whereas Doenjang confirmed promise in assuaging menopausal signs and modifying intestine microbiota, its results on weight problems and irritation have been restricted.

Conclusions

Conventional Doenjang fermented with helpful microorganisms was discovered to be superior in its skill to mitigate menopausal signs as in comparison with industrial Doenjang. However, a major discount in Kupperman index scores was noticed throughout all teams, with probably the most notable enchancment noticed in LDC recipients.

LDL levels of cholesterol decreased in each conventional Doenjang teams, thus indicating its potential cardiovascular advantages. Though Doenjang was not related to anti-obesity or anti-inflammatory results, its remedy positively influenced intestine microbiota by growing helpful micro organism and decreasing the degrees of dangerous micro organism.

Taken collectively, these findings reveal that conventional Doenjang has the potential to successfully alleviate menopausal signs, significantly when contemplating cardiovascular well being, with implications for bettering intestinal well being by way of its influence on intestine microbiota.

Some limitations of the present research embody the shortcoming to manage members’ way of life components, the brief research period, and the small pattern measurement. Thus, future research with bigger samples and longer durations to elucidate the therapeutic potential of Doenjang.