Scientists on the Karolinska Institute in Sweden have carried out a scientific assessment and meta-analysis to find out the connection between dietary antioxidant consumption and kind 2 diabetes danger.
The research is printed within the journal Advances in Vitamin.
Overview: Nutritional vitamins C, E, and beta-carotene and danger of kind 2 diabetes: a scientific assessment and meta-analysis. Picture Credit score: alicja neumiler / Shutterstock
Background
Sort 2 diabetes is a critical metabolic illness characterised by lowered secretion or impaired functioning of insulin and subsequent enhance in blood glucose degree (hyperglycemia). Insulin resistance and pancreatic beta-cell dysfunction are two main hallmarks of the illness.
Greater than 10% of the worldwide inhabitants is at the moment affected by kind 2 diabetes. Its prevalence is sharply growing worldwide primarily due to an growing inclination in direction of unhealthy meals habits and sedentary existence.
Weight-reduction plan performs an vital function in regulating the physique’s metabolism, amongst numerous life-style elements. Proof signifies that an elevated adherence to wholesome diets, such because the Mediterranean or DASH (Dietary Method to Cease Hypertension), can considerably cut back the chance of kind 2 diabetes. The basic attribute of those diets is the next consumption of plant-based meals wealthy in antioxidants, together with nutritional vitamins C, E, and beta-carotene.
On this systematic assessment and meta-analysis, scientists have assessed whether or not consumption of dietary nutritional vitamins C, E and beta-carotene can cut back the chance of kind 2 diabetes.
Examine design
The scientists searched numerous digital databases to determine research investigating the affiliation between dietary intakes, circulating ranges, or supplementation of vitamin C, E, and beta-carotene and kind 2 diabetes incidence or insulin resistance/sensitivity and beta cell operate in non-diabetic people.
The ultimate screening led to the identification of 25 potential observational research and 15 randomized managed trials. Average and critical dangers of bias have been noticed in 21 and 4 observational research, respectively. Amongst randomized managed trials, 13 had a low danger of bias, and a pair of had some issues.
Essential observations
The research discovered that average intakes of nutritional vitamins C, E, and beta-carotene can cut back the chance of kind 2 diabetes.
Vitamin C
The meta-analysis of observational research revealed {that a} vitamin C consumption of as much as 70 mg per day can cut back kind 2 diabetes danger by 24%. Nevertheless, no additional danger discount was noticed for an consumption larger than this degree.
An inverse affiliation was noticed between dietary consumption of vitamin C and insulin resistance. Vitamin C consumption additionally confirmed a optimistic affect on beta cell operate.
Vitamin E
The meta-analysis of observational research revealed that the vitamin E consumption of as much as 12 mg per day can cut back the chance of kind 2 diabetes by 28%. Just like vitamin C, no additional danger discount was noticed for an consumption larger than this degree.
The meta-analysis of randomized scientific trials revealed that vitamin E supplementation doesn’t have any protecting impact towards kind 2 diabetes growth. Nevertheless, vitamin E supplementation confirmed a optimistic affect on insulin sensitivity.
Beta-carotene
The meta-analysis of observational research revealed that the beta-carotene consumption of as much as 4 mg per day can cut back the chance of kind 2 diabetes by 22%. No additional danger discount was noticed above this degree.
The meta-analysis of randomized managed trials revealed that beta-carotene supplementation can not cut back the chance of kind 2 diabetes. It was additionally noticed that circulating beta-carotene can cut back insulin resistance and enhance insulin sensitivity.
Examine significance
This systematic assessment and meta-analysis discovered an inverse affiliation between dietary and circulating nutritional vitamins C, E, and beta-carotene and the chance of kind 2 diabetes. Nevertheless, no protecting efficacy of supplementation with these antioxidants has been noticed towards kind 2 diabetes.
The strong antioxidant properties of those nutritional vitamins are primarily chargeable for their anti-diabetic results. Vitamin C is a water-soluble vitamin generally present in fruit and veggies. It will probably take away free radicals within the physique’s hydrophilic compartments and regenerate vitamin E from its oxidized kind.
Vitamin E is a fat-soluble vitamin generally present in nuts, seeds, and vegetable oils. It will probably stop lipid peroxidation and shield lipid elements of the physique, reminiscent of cell membranes. Beta-carotene is a fat-soluble provitamin A carotenoid generally present in fruit and veggies. Just like vitamin E, beta-carotene can shield lipid elements of the physique from free radical-mediated injury.
Article Revisions
- Mar 27 2024 – Addition of Graphical summary illustration.
