Doxycycline exhibits promise in decreasing deaths and seizures from nodding syndrome

A brand new examine suggests {that a} course of the drug doxycycline can lower acute seizure-related hospitalization and deaths associated to nodding syndrome.

Nodding syndrome is a neurological situation that causes extreme and debilitating psychological and bodily disabilities and life-threatening seizures. The illness primarily impacts kids and adolescents residing in components of East Africa.

Latest analysis into the origins of nodding syndrome linked it to an infection with a parasite answerable for the illness onchocerciasis, generally referred to as river blindness.

Primarily based on this discovery, in analysis funded by the UK Medical Analysis Council, Dr Richard Idro from Makerere College labored with colleagues in Uganda, Liverpool Faculty of Tropical Drugs (LSTM), College of Oxford, Nationwide Institutes of Well being, USA, Ministry of Well being, Uganda, and the London Faculty of Hygiene & Tropical Drugs to check whether or not a course of doxycycline, a drug that may remedy onchocerciasis, would profit sufferers affected by nodding syndrome.

The outcomes, printed in Lancet World Well being, confirmed that doxycycline can be utilized to regulate an infection induced extreme seizures in sufferers with nodding syndrome and considerably scale back antibodies to the parasite answerable for onchocerciasis.

The examine’s lead writer Dr Richard Idro mentioned: “This examine not solely confirms the affiliation between an infection by the filarial worm Onchocerca volvulus but in addition means that prevention of fever-causing infections with antibiotic prophylaxis can enormously scale back hospitalizations and deaths in nodding syndrome.”

Professor Mark Taylor from LSTM co-authored the paper and pioneered doxycycline remedy to deal with onchocerciasis. He mentioned: “This examine demonstrates yet one more good thing about utilizing doxycycline remedy for onchocerciasis. Though it nonetheless leaves questions on the reason for nodding syndrome, it does construct on different proof exhibiting that therapy of onchocerciasis brings actual advantages to these affected by this situation and extra advantages by decreasing hospitalization and deaths related to nodding syndrome.”

Professor Colebunders, an Honorary Professor at LSTM and a worldwide knowledgeable on nodding syndrome, labored with colleagues from the College of Antwerp and specialists from the onchocerciasis neighborhood to develop suggestions for well being policymakers to extend the protection of onchocerciasis remedies.

They instructed giving free entry to anti-seizure treatment in impoverished communities affected by onchocerciasis-associated epilepsy (OAE) and for the scientific neighborhood to accentuate their efforts to determine the underlying illness mechanism to offer new approaches to their therapy and scientific administration.

Now that we all know doxycycline can restrict the seizures related to nodding syndrome, it’s important that victims are given entry to the drug. We should additionally redouble our efforts to find what’s inflicting this debilitating illness so we will discover higher remedies and, probably, a method to forestall it totally.”

Professor Colebunders, Honorary Professor, LSTM

Dr Idro’s examine paves the best way for future analysis on the position of doxycycline as a therapy for nodding syndrome and prompts additional investigations into its exact trigger.